|
KMID : 0616120070380040382
|
|
Korean Journal of Pharmacognosy
2007 Volume.38 No. 4 p.382 ~ p.386
|
|
|
Isolation of Melanogenesis Inhibitors from Cinnamomi Cortex
|
|
Jung Hee-Wook
Lee Seung-Ho
Son Jong-Keun
Choi Ji-Young
Oh Joon-Seok
Choi Een-Hyang
Kim Dong-Chun
Lee Jong-Koo
Kim Jeong-Ah
Park Seong-Hee
|
|
|
Abstract
|
|
|
Cinnamomi Cortex (Lauraceae), the dried bark of Cinnamomum cassia BLUME, has been used as traditional Chinese
medicine for its stomachic, astringent, carminative, antispasmodic, antibacterial, antifungal properties. Four compounds
were isolated from the MeOH extract of Cinnamomi Cortex, and their structures were identified as trans-cinnamic acid (1),
β-sitosterol (2), bis(2-methylheptyl)phthalate (3), coumarin (4) by comparison of their physical and spectral data with those reported in the literature. These compounds were tested melanogenesis inhibitory effect on B-16 mouse melanoma cell lines. Among them, trans-cinnamic acid (1) showed the most potent inhibitory effect on melanogenesis with IC50 value of 13 μg/ml. Arbutin, positive control, exhibited an IC50 value of 29 μg/ml.
|
|
|
KEYWORD
|
|
|
Cinnamomi Cortex, trans-cinnamic acid, melanogenesis inhibitor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|